We are thrilled to announce that Juhyuk Park’s paper, "Integrated platform for multiscale molecular imaging and phenotyping of the human brain” has been published in Science Magazine.
Park, Wang, Guan et al. Science 384, eadh9979 (2024)
Link: https://lnkd.in/dyhbTEty
To develop new treatments or innovative drugs for intractable/incurable diseases, it is crucial to gain deeper understandings of complex human biological systems at various scales. However, the large size and fragile properties of human organs present numerous challenges, causing most research to rely on small, sectioned tissue samples.
In our paper, we present a biotechnology platform for 3D human brain mapping that addresses these challenges by integrating three innovations in Materials Science (mELAST), Mechanical Engineering (MEGAtome), and Computer Science (UNSLICE).
Our advanced polymeric network (mELAST) transforms biological tissues into unique biomaterials that are transparent, elastic, size-adjustable, and chemically and thermally resistant, while preserving endogenous biomolecules. This tissue processing method has enabled us to image various biomolecules at multiple scales from the same, thick, large-scale human brain tissues, providing valuable data on Alzheimer's disease.
We believe this platform can be widely applied to all human organs, laying the foundation for creating a cellular and subcellular level 3D map of the entire human body.
This work was supervised by Prof. Kwanghun Chung at MIT and co-led by me, Dr. Ji Wang, and Dr. Webster Guan. Also it includes other co-authors: Lars Gjesteby, Dylan Pollack, Lee Kamentsky, Nicholas Evans, Jeff Stirman, Xinyi Gu, Victor Chuanxi Zhao, Slayton Marx, Minyoung Evelyn Kim, Seo Woo Choi, Michael Snyder, David Chavez, Clover Su, Yuxuan Tian, Chang Sin Park, Qiangge Zhang, Dae Hee Yun, Mira M, Guoping Feng, X. William Yang, C. Dirk Keene, Patrick Hof, Satrajit Ghosh, Matthew P. Frosch, and Laura J. Brattain.
